The colonization of the islands and the mainland of Southeast Asia by the Europeans began in the 16th century. It all begun with the determination to take over the spice trade. It is important to note that the region of Southeast Asia is divided into two regions (Lewis, 2016). They are the mainland and the island zones. The mainland regions of the Southeast Asia are made up of eleven states which include Thailand, Cambodia, Vietnam, Laos and Burma. On the other hand, the island zones comprise Singapore, Malaysia, Brunei, Philippines, and Indonesia. The Europeans conquered these zones using distinct techniques. The paper seeks to provide comparisons which exist between the patterns of European conquests.Monopoly of the spice trade: The conquests of the island nations located in Southeast Asia were conducted in an attempt to take over the entire spice industry. Spices which were highly traded at the time included pepper, cloves and nutmeg. The European takeover of the spice trade was attributed to the desire to remove all the middlemen associated with the trade. The pattern of the trade that was in existence was the principal factor which prompted the conflict leading to European conquests (Rettig, and Hack, 2005). The Europeans wanted to take over the trading routes and the primary distributors. In other words, their conquests of the islands of Southeast Asia were aimed at taking hold of the monopoly of the spice trade. They employed various techniques. These techniques involved establishing trading ports. In addition to setting up trading ports, they employed superior military strength to take over the highly lucrative business. In as much as the Europeans initially entered the spice trade n an attempt to take it over, they ended up conquering and monopolizing the islands. Considering that the Europeans left a lot of destruction in their wake, many of the islands ended up devastated by the presence of the Europeans. One example concern the European takeover of the Malacca. Their presence signified the destruction of the Malacca city-state.